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动脉粥样硬化与黄酮类化合物的作用 被引量：2

Atherosclerosis and the effects of flavonoids
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摘要 本文初步论述了动脉粥样硬化(AS)的形成理论,着重论述了内皮细胞,及内皮细胞上凝集素样氧化低密度脂蛋白受体-1在AS形成中的作用及机制。并论述了黄酮类化合物抗AS的进展,对进一步开发新药提出了自己的观点。 The present paper overviewed the theories about the formation of atherosclerosis, discussed the effects of endothelial cells as well as lectin-like oxidized low-density lipoprotein receptor-1 on the progress of AS.It also overviewed the researches focusing on the flavonoids on the treatment of AS,and provided some opinions on the development of new medicines for treatment of AS.
作者 鲍美华 刘卫平 周畅
机构地区 长沙医学院
出处 《长沙医学院学报》 2008年第2期42-45,41,共5页 Journal of Changsha Medical University
关键词 动脉粥样硬化 内皮细胞 LOX-1 黄酮 Atherosclerosis endothelial cells low-density lipoprotein flavonoids
分类号 R543 [医药卫生—心血管疾病]
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参考文献17

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同被引文献47

  • 1甄艳军,侯建明,朱方,周晓红,李国明,王耀民,何立,李梅.木贼对大鼠高脂血症及主动脉内膜早期粥样硬化病变的影响[J].中国老年学杂志,2004,24(7):643-645. 被引量：16
  • 2马小欣,赵慧颖,徐宝华.Rho/Rho激酶与动脉粥样硬化及冠心病的关系[J].中国微循环,2007,11(2):138-141. 被引量：9
  • 3张娟综述 王绿娅 王拥军审校.氧化型低密度脂蛋白和动脉粥样硬化[J].中国动脉硬化杂志,2002,39(1):60-64.
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  • 7Zhu X,Li Z,Li C,et al.Ginkgo biloba extract and aspirin Synergistically attenuate activated platelet-induced ROS production and LOX-1 expression in human coronary artery endothelial cells[J].Phytomedicine,2013,20(2):114-119.
  • 8Li D,Mehta JL.Upregulation of endothelial receptor for oxidized LDL(LOX-1)by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells:Evidence from use of antisense LOX-1 mRNA and chemical inhibitors[J].Arterioscler Thromb Vasc Biol,2000,20(4):1 116-1 122.
  • 9Li DY,Zhang YC,Philips MI,et al.Upregulation of endothelial receptor for oxidized low-density lipoprotein(LOX-1)in cultured human coronary artery endothelial cells by angiotensin ii type 1receptor activation[J].Circ Res,1999,84(9):1 043-1 049.
  • 10Hu C,Dandapat A,Sun L,et al.Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectinlike oxidized low-density lipoprotein receptor-1 deletion[J].Hypertension,2008,52(3):556-562.

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长沙医学院学报
2008年 第2期

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