环氧二十碳三烯酸心血管保护作用研究进展

Research Progress of Protective Effects of Epoxyeicosatnenoic Acid on Cardiovascular Disease

目心血管疾病是危害人类健康的严重疾病,也是造成人类死亡的主要原因之一。大量研究表明心脏前后负荷增大、冠状动脉血液灌流不足、心肌组织氧气和能量供应障碍是导致心血管疾病发生的主要机制。环氧二十碳三烯酸(EET)是一种内源性心血管活性物质,它可作用于心血管疾病的多种发病机制,如抗心肌缺血、抗炎症反应、改善内皮功能、抗血小板黏附与聚集等作用,在治疗各种心血管疾病中发挥了重要作用。本文就EET对心血管的保护作用及其机制做一综述,为研究开发新的治疗心血管疾病的药物提供理论依据。

Cardiovascular disease is not only a serious disease that risks to human health,but also one of the main causes of death.Numerous studies show that the main mechanism that lead to cardiovascular disease is the load of heart before and after increases,coronary artery blood perfusion is not enough,cardiac muscle tissues oxygen and energy supply barriers.Epoxyeicosatrienoic acid(EE is an endogenous cardiovascular active substances,it can act on the various pathogenesis of cardiovasculal-diseases,such as myocardial isehemia,inflan maatory response,improving endothelial function,anti-platelet adhesion and aggregation and so on,and it plays an important role in the treatment of various cardiovascular diseases.In this paper,protective effects and mechanisms of EET on the cardiovascular was to do a review,so as to provide theoretical basis for developing new drugs of curing cardiovascular disease.