鼻力宝胶囊治疗大鼠慢性鼻炎微循环的实验研究

目的:探讨鼻力宝胶囊治疗大鼠慢性鼻炎的疗效及其作用机理。方法:SD大鼠饲养一周以适应环境后随机分为4组,鼻力宝胶囊治疗组,藿胆丸治疗组,模型对照组,空白对照组。各组分别进行血液流变学测试。结果:血液流变学测试:①模型对照组的血液流变学指标明显高于空白对照组(P【0.01),②经过治疗15天后,各治疗组与模型组比较血流变指标,差异显著(P【0.05);③藿胆丸治疗组与空白对照组比较血流变指标有差异(P【0.05);④鼻力宝治疗组血流变与藿胆丸治疗组比较,差异显著(P【0.01);⑤鼻力宝与空白对照组比较血流变指标,差异不显著(P】0.10)。结论:鼻力宝胶囊可以改善慢性鼻炎大鼠的血液流变学指标。

Objective To observe the effect of Bilibao capsule on microcirculation in white rats with chronic rhinitis. Methods White rats were randomly divided into four groups. One treatment groups were administrated with Bilibao capsule. Another treatment groups were administrated with Huo-dan Pill, mode empty control group, and empty control group with a test of hemorrheology changes for all groups.Results 1 the target of hemorrheology changes in treatment group was significantly higher than that in control group. (P<0.01) 2 After 15 days, there was a significant difference in the changes of hemorrheology between every treatment groups and the model control group. 3 there was a siginificant difference in the changes of hemorrheology between the huo-dan pil group and the empty control group.(p<0.05) 4 there was a significant difference in the changes of hemorrheology between the Bilibao capsule group and the Huo-duo pill group.(P<0.01) 5 there was a weak difference in the changes of hemorrheology between the Bilibao capsule group and the empty control group. Conclusion Bilibao capsule can change the target of hemorrhology changes in white rats with chronic thinitis.