摘要
Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia （M.corchorifolia）aerial part extracts.Methods:Antioxidant activitywas evaluated by using three free radicals（Superoxide,Hydroxyl and DPPH） and hepatoprotective activity was assessed against CCl<sub>4</sub> induced liver intoxication in ruts.Results:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free radicals.Among all extracts methanol extract showed better activity with percentage protection of SGOT（78.98%）,SGPT（79.65%）,ALP（82.48%） and total bilirubin（80.0%）levels against CCl<sub>4</sub> liver intoxication and also methanolic extract showed better activity with IC<sub>50</sub> values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μg.Conclusions:From the results obtained during the study it could be concluded that M.corchorifolia aerial part extracts have antioxidant and hepaloprotective components.Further study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.
Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia （M.corchorifolia）aerial part extracts.Methods:Antioxidant activitywas evaluated by using three free radicals（Superoxide,Hydroxyl and DPPH） and hepatoprotective activity was assessed against CCl4 induced liver intoxication in ruts.Results:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free radicals.Among all extracts methanol extract showed better activity with percentage protection of SGOT（78.98%）,SGPT（79.65%）,ALP（82.48%） and total bilirubin（80.0%）levels against CCl4 liver intoxication and also methanolic extract showed better activity with IC50 values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μg.Conclusions:From the results obtained during the study it could be concluded that M.corchorifolia aerial part extracts have antioxidant and hepaloprotective components.Further study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.
