摘要
Objective:To study the expression of ALDHI in colon cancer and its clinical significance. Methods:The expression of ALDH1 was examined in 98 surgical specimens of primary colonic carcinoma and 15 normal colon tissues with immunohistochemistry method.The correlations of the expression with clinicopathological parameters and prognosis of colon cancer were analyzed. Results:The positive rate of expression of ALDH1 was 76.5%(75/98) in the cancer tissues and 13.3%(2/15) in normal colon tissues.There were an obvious statistical difference(P【0.05) between the two groups,The ALDH1 expression was significantly correlated with the histological grade. TNM stages and lymph node metastasis in colon cancer(P【0.05).It was also related with patients’ survival time,those with positive expressions had a poor prognosis(P【0.05).Conclusions:The results suggeste that the overexpression of ALDHl plays important roles in proliferation and progression in colon cancer,the ALDHl may be a valuable marker to predict the biological behavior and trend of metastasis of colon cancer.
Objective:To study the expression of ALDHI in colon cancer and its clinical significance. Methods:The expression of ALDH1 was examined in 98 surgical specimens of primary colonic carcinoma and 15 normal colon tissues with immunohistochemistry method.The correlations of the expression with clinicopathological parameters and prognosis of colon cancer were analyzed. Results:The positive rate of expression of ALDH1 was 76.5%(75/98) in the cancer tissues and 13.3%(2/15) in normal colon tissues.There were an obvious statistical difference(P<0.05) between the two groups,The ALDH1 expression was significantly correlated with the histological grade. TNM stages and lymph node metastasis in colon cancer(P<0.05).It was also related with patients’ survival time,those with positive expressions had a poor prognosis(P<0.05).Conclusions:The results suggeste that the overexpression of ALDHl plays important roles in proliferation and progression in colon cancer,the ALDHl may be a valuable marker to predict the biological behavior and trend of metastasis of colon cancer.
