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Bioinformatics analysis of breast cancer bone metastasis related geneCXCR4 被引量：7

Bioinformatics analysis of breast cancer bone metastasis related geneCXCR4
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摘要 Objective:To analyze breast cancer bone metastasis related gene-CXCR4.Methods:This research screened breast cancer bone metastasis related genes by high-flux gene chip.Results:It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations.The expression of chemokine receptor CXCR4 was obviously upregulated in the tissue with breast cancer bone metastasis.Compared with the tissue without hone metastasis,there was significant difference,which indicated that CXCR4 played a vital role in breast cancer bone metastasis.Conclusions:The hioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis,target gene therapy and evaluation of prognosis. Objective:To analyze breast cancer bone metastasis related gene-CXCR4.Methods:This research screened breast cancer bone metastasis related genes by high-flux gene chip.Results:It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations.The expression of chemokine receptor CXCR4 was obviously upregulated in the tissue with breast cancer bone metastasis.Compared with the tissue without hone metastasis,there was significant difference,which indicated that CXCR4 played a vital role in breast cancer bone metastasis.Conclusions:The hioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis,target gene therapy and evaluation of prognosis.
作者 Heng-Wei Zhang Xian-Fu Sun Ya-Ning He Jun-Tao Li Xu-Hui Guo Hui Liu
机构地区 Department of Breast Affiliated Cancer Hospital of Zhengzhou University
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第9期732-738,共7页 亚太热带医药杂志（英文版）
基金 supported by the Projeet of International Science and Technology Cooperation of Henan Province(094300510014)
关键词 BREAST cancer BONE METASTASIS CXCR4 BIOINFORMATICS analysis Breast cancer bone metastasis CXCR4 Bioinformatics analysis
分类号 R737.9 [医药卫生—肿瘤]
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Asian Pacific Journal of Tropical Medicine
2013年 第9期

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