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An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells 被引量：9

An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells
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摘要 Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus in provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established.Then,the umbilical cord mesenchymal stem cells were injected into the rats via tail vein.Visual and histopathiological changes of the experimental rats were observed.Results:After the injection,the rats in the prevention group and treatment group had remarkably better survival status than those in the control group.The histological observations revealed that the former also had better intestinal mucosa structure,more regenerative cells and stronger proliferation activity than the latter.Conclusions:Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats. Objective:To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus in provide clinical therapeutic basis for radiation sickness.Methods:Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established.Then,the umbilical cord mesenchymal stem cells were injected into the rats via tail vein.Visual and histopathiological changes of the experimental rats were observed.Results:After the injection,the rats in the prevention group and treatment group had remarkably better survival status than those in the control group.The histological observations revealed that the former also had better intestinal mucosa structure,more regenerative cells and stronger proliferation activity than the latter.Conclusions:Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.
作者 Rui Wang Wei Yuan Qiang Zhao Peng Song Ji Yue Shi-De Lin Ting-Bao Zhao
机构地区 Jinan Miltary General Hospital People's Hospital of Zhangqiu
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第12期968-971,共4页 亚太热带医药杂志（英文版）
基金 supported by Wu Zuze Science and Technology Development Foundation of Beijing
关键词 RADIOACTIVE contamination Human UMBILICAL CORD MESENCHYMAL stem cells ACUTE RADIOACTIVE ENTERITIS Rat Radioactive contamination Human umbilical cord mesenchymal stem cells Acute radioactive enteritis Rat
分类号 R818 [医药卫生—放射医学]
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参考文献9

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二级参考文献16

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Asian Pacific Journal of Tropical Medicine
2013年 第12期

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