摘要
Objective:To evaluate antiplasmodial and analgesic activities of ethanolic leaf extract/ fractions of Panicum maximum.Methods:The crude leaf extract(47-190 mg/kg) and fractions (chlor of orm,ethyl acqeous and methanol;96 mg/kg) of Panicum maximum were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity against chemical and heat-induced pains.The antiplasmodial activity during early and established infections as well as prophylactic were investigated.Artesunate at 5 mg/kg and pyrimethamine at 1.2 mg/kg were used as positive controls.Analgesic activity of the crude extract/fractions was also evaluated against acetic acid,formalin and heat-induced pains.Results:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic,suppressive and curative models in mice.These reductions were statistically significant(P【0.001).They also improved the mean survival time from 13 to 28 days compared with control(P【0.001).The activities of extract/ fractions were incomparable to that of the standard drugs(Artesunate and pyrimethamine).On chemically and thermally-induced pains.the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in mice.These inhibitions were statistically significant(P【0.001) and in a dose-dependent fashion.Condusions:Panicum maximum leaf extract has antiplasmodial and analgesic activities which may in part be mediated through the chemical constituents of the plant.
Objective:To evaluate antiplasmodial and analgesic activities of ethanolic leaf extract/ fractions of Panicum maximum.Methods:The crude leaf extract(47-190 mg/kg) and fractions (chlor of orm,ethyl acqeous and methanol;96 mg/kg) of Panicum maximum were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity against chemical and heat-induced pains.The antiplasmodial activity during early and established infections as well as prophylactic were investigated.Artesunate at 5 mg/kg and pyrimethamine at 1.2 mg/kg were used as positive controls.Analgesic activity of the crude extract/fractions was also evaluated against acetic acid,formalin and heat-induced pains.Results:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic,suppressive and curative models in mice.These reductions were statistically significant(P<0.001).They also improved the mean survival time from 13 to 28 days compared with control(P<0.001).The activities of extract/ fractions were incomparable to that of the standard drugs(Artesunate and pyrimethamine).On chemically and thermally-induced pains.the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in mice.These inhibitions were statistically significant(P<0.001) and in a dose-dependent fashion.Condusions:Panicum maximum leaf extract has antiplasmodial and analgesic activities which may in part be mediated through the chemical constituents of the plant.
