摘要
Objective:To investigate the role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of irritable bowel syndrome（IBS）,as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β<sub>1</sub> was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β<sub>1</sub>（P】0.05）.Interestingly,there was a significant correlation between Runx3 protein and TGF-β<sub>1</sub> in patients with IBS（P【0.05）.Conclusions:The role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of IBS remains to be further studied.
Objective:To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β_1 was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β_1(P>0.05).Interestingly,there was a significant correlation between Runx3 protein and TGF-β_1 in patients with IBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β_1 in the pathogenesis of IBS remains to be further studied.
基金
Supported by Natural Scienee Foundation of Hainan Province(No 30855)
