摘要
Objective:To develop floating microspheres of cefpodoxime proxetil(CP) in order to achieve an extended retention in the upper GIT for 12 hour.Methods:The microspheres were prepared by non aqueous solvent evaporation method using different ratios of cefpodoxime proxetil, hydroxyl propyl methyl cellulose(HPMC K4M ) and ethyl cellulose(1:1:1,1:1:2,1:1:3,1:1:4, 1:1:5 & 1:1:6),in the mixture of dichloromethane and ethanol at ratio of(l:l),with tween80 as the surfactant.Results:The floating microspheres was extended over 10-12 hours and were characterized by particle size analysis(75-600μm),buoyancy percentage(68.1%-85.4%), drug entrapment efficiency(67.5%-88.8%),%yield(50.50%-77.31%) and in vitro drug release was studied for 12 hours.Conclusions:The floating microspheres show better result and it may be use full for prolong the drug release in stomach and improve the bioavailability.
Objective:To develop floating microspheres of cefpodoxime proxetil(CP) in order to achieve an extended retention in the upper GIT for 12 hour.Methods:The microspheres were prepared by non aqueous solvent evaporation method using different ratios of cefpodoxime proxetil, hydroxyl propyl methyl cellulose(HPMC K4M ) and ethyl cellulose(1:1:1,1:1:2,1:1:3,1:1:4, 1:1:5 & 1:1:6),in the mixture of dichloromethane and ethanol at ratio of(l:l),with tween80 as the surfactant.Results:The floating microspheres was extended over 10-12 hours and were characterized by particle size analysis(75-600μm),buoyancy percentage(68.1%-85.4%), drug entrapment efficiency(67.5%-88.8%),%yield(50.50%-77.31%) and in vitro drug release was studied for 12 hours.Conclusions:The floating microspheres show better result and it may be use full for prolong the drug release in stomach and improve the bioavailability.
