摘要
The research scenario for malaria has improved in the last three decades to understand the epidemiology and host immune responses to plasmodial infection.Due to the augmented episodes of resistance development against the commonly used antimalarials in plasmodium parasites,especially in Plasmodium falciparum,neutralization of infection through effective vaccine(s) remains the feasible alternative in malaria control.In this direction,lot of attention was paid towards the identification of stage specific malaria antigens targeted by host ’s immune system.Preparation of synthetic or recombinant peptides and evaluation of their immunogenecity in naturally occurring antibody response were also given much importance,as these studies could help in finding potential candidates for future malaria vaccine(s).Attention was also paid.on the pathogenic consequences of antibody formation in malaria infection as polyclonal activation of B cells,which is a very prominent feature in malaria infection.Formation of circulating immune complexes in chronic malaria infection was also viewed as pathogenic parameter of severe malaria.The present survey focuses mainly on protective and pathogenic aspects of malaria antibodies(eliciting against various,stage specific antigens),and future research plan in antibodymediated immune response.
The research scenario for malaria has improved in the last three decades to understand the epidemiology and host immune responses to plasmodial infection.Due to the augmented episodes of resistance development against the commonly used antimalarials in plasmodium parasites,especially in Plasmodium falciparum,neutralization of infection through effective vaccine(s) remains the feasible alternative in malaria control.In this direction,lot of attention was paid towards the identification of stage specific malaria antigens targeted by host 's immune system.Preparation of synthetic or recombinant peptides and evaluation of their immunogenecity in naturally occurring antibody response were also given much importance,as these studies could help in finding potential candidates for future malaria vaccine(s).Attention was also paid.on the pathogenic consequences of antibody formation in malaria infection as polyclonal activation of B cells,which is a very prominent feature in malaria infection.Formation of circulating immune complexes in chronic malaria infection was also viewed as pathogenic parameter of severe malaria.The present survey focuses mainly on protective and pathogenic aspects of malaria antibodies(eliciting against various,stage specific antigens),and future research plan in antibodymediated immune response.
