摘要
Objective:To determined the antiparasitic activity of the isolated chitosan from Penicillium viridicatum,Penicillium aurantiogriseum and commercial chitosan against protoscolicidal of hydatid cysts were determined.Methods:After isolating chitosan from fungal cell walls,four concentrations(50,100,200,400μg/mL)of each type of prepared chitosan and commercial chitosan were used for 10,30,60,and 180min,respectively.Results:Among different type of chitosan,commercial chitosan with the highest degree of deacetylation showed high scolicidal activity in vitro.Fungal chitosan could be recommended,as good as commercial chitosan,for hydatic cysts control.Conclusions:It seems to be a good alternative to synthetic and chemical scolicidal.
Objective:To determined the antiparasitic activity of the isolated chitosan from Penicillium viridicatum,Penicillium aurantiogriseum and commercial chitosan against protoscolicidal of hydatid cysts were determined.Methods:After isolating chitosan from fungal cell walls,four concentrations(50,100,200,400μg/mL)of each type of prepared chitosan and commercial chitosan were used for 10,30,60,and 180min,respectively.Results:Among different type of chitosan,commercial chitosan with the highest degree of deacetylation showed high scolicidal activity in vitro.Fungal chitosan could be recommended,as good as commercial chitosan,for hydatic cysts control.Conclusions:It seems to be a good alternative to synthetic and chemical scolicidal.
基金
supported by a grant from Student Research Committee of Mazandaran University of Medical Sciences.Sari.Iran(Grant No.91/150)
