摘要
Objective:To investigate the cytotoxicity of the crude ethanol extract of the rhizome of Zingiber zerumbel(Z.zerumbet)(L)Smith,and Curcuma zedoaria(C.zedoaria)Rosc,against Artemia salina Leach.Methods:Fresh rhizomes of Z.zerumbet(L)Smith,and C.zedoaria Rose,were extracted separately in cold with ethanol(2.5 L)and after concentration a brownish syrupy suspension of ethanol extracts of Z.zerumbel(L)Smith,and C.zedoaria Rose,was obtained.The cytotoxic effect of the crude ethanol extracts of both plants was determined by brine shrimp lethality bioassay.Results:Crude ethanol extracts of the rhizome of Z.zerumbel(L)Smith,showed the highest cytotoxicity(LC_(50)was 1.24μg/mL)against brine shrimp nauplii as compared with C.zedoaria Rose.(LC_(50)was 33.593μg/mL)after 24 h of exposure.Conclusions:It can be concluded that the rhizome of Z.zerumbet(|L)Smith,and C.zedoaria Rose,can be used as a source of cytotoxic agent.
Objective:To investigate the cytotoxicity of the crude ethanol extract of the rhizome of Zingiber zerumhel(Z.zerumbet)(L) Smith.and Curcuma zedoaria(C.zedoaria) Rose,against Artemia salina Leach.Methods:Fresh rhizomes of Z.zerumhel(L) Smith.and C.zedoaria Rosc.were extracted separately in cold with ethanol(2.5 L) and after concentration a brownish syrupy suspension of elhanol extracts of Z.zerumhel(L) Smith.and C.zedoaria Rosc,was obtained.The cytotoxic effect of the crude ethanol extracts of both plants was determined by brine shrimp lethality bioassay.Results:Crude ethanol extracts of the rhizome of Z.zerumbet(L) Smith,showed the highest cytotoxicity(LC_(50) was 1.24μg/mL) against brine shrimp uauplii as compared with C.zedoaria Rosc.(LC_(50) was 33.593μg/mL) after 24 h of exposure.Conclusions:It can be concluded that the rhizome of Z.zerumbet(L) Smith.and C.zedoaria Rosc.can be used as a source of cytotoxic agent.
基金
supported by Ministry of Science,Information and Communication Technology,Bangladesh(grant No.12/2008-2009)
