大鼠大脑两半球机能不对称性个体发生的初步探讨——苯异丙胺诱发婴鼠旋转行为的实验研究

STUDY ON ONTOGENY OF FUNCTIONAL ASYMMETRY OF THE TWO CEREBRAL HEMISPHERES IN RATS——AN EXPERIMENT ON ROTATIONAL BEHAVIOR INDUCED BY AMPHETAMINE IN NEONATAL RATS

断奶前Wistar婴鼠168只,分为0、2、4、6……20日龄共11个日龄组。记录每只动物腹腔注射苯异丙胺(5毫克/公斤)所诱发的旋转行为,以研究大鼠大脑两半球机能不对称性的个体发生。本实验观察到0日龄(出生后0—12小时)婴鼠即可被苯异丙胺诱发低水平的旋转行为,其旋转行为水平随日龄的增长而提高。该实验结果表明大鼠在出生时大脑两半球机能已存在不对称性特征。

168 Wistar rat pups were assigned to 11 age groups from 0, 2, 4, 6……to 20 days. All subjects were tested for the rotational behavior inducedby amphetamine (50mg/kg i. p.). The purpose is to study ontogeny offunctional asymmetry of the two cerebral hemispheres in rats. The test showed that the rotation with low level in O-day-1 old (post-natal 0-12 hrs) pups can be induced by amphetamime, and the level ofrotation was enhanced with each passing day. The results indicate that inrats the two cerebral hemispheres were characterized by asymmetry atbirth.