摘要
本工作采用穿梭式电击回避反应法和脑啡肽的放射免疫测定法,分析比较了大鼠作业成绩与脑内壳氨酸脑啡肽(Leu-enkephalin,LEK)含量的关系,在本实验条件下,观察到作业成绩不良组纹状体内LEK含量显著高于成绩优良组和对照组,并由实验证明,它们之间的差异不是由于在实验中接受电击的次数或电击总量不同造成的。这一结果提示,内源性亮氨酸脑啡肽可能参与记忆获得的调制。
Rats were trained in a shuttle avoidance task. Brain LEK levels weremeasured in rats after 5 training sessions. LEK level of stritum increasedin the rats with low performance score compared with rats with highperformance score (P<0.05) and controls (P<0.01). No difference in LEKlevel between rats with high performance score and controls was found.The data indicated that the foo?-shock stimulation was not attributableto the difference in LEK level. These results suggest that endogenousLEK may be involved in the modulation of acquisition of shuttle avoid-ance responses.
出处
《心理学报》
1988年第2期205-210,共6页
Acta Psychologica Sinica
基金
国家自然科学基金
