可乐宁、安定结合心理治疗戒除烟瘾的双盲对照研究

Effects of clonidine,valium and placebo in smoking cessation:A double blind trial

用双盲法将107例戒烟就诊者随机分为可乐宁组(38例)、安定组(34例)和安慰剂组(35例),同时各组加用同样的心理治疗。结果发现三种治疗措施皆有明显效果。治疗结束时各组戒烟率分别为76.3%、41.1%和42.8%,随访时(平均4.5月)各组戒烟率为63.2%、41.2%和40.0%.可乐宁组戒烟者在治疗结束和随访时的平均每日吸烟量皆低于其他两组(P<0.01)而安定组和安慰剂组差异皆不显著(P>0.05),同时还发现可乐宁组戒烟者的戒烟症状明显轻于其他两组且戒烟者对可乐宁的评价最好,从而证明可乐宁具有治疗烟瘾的临床价值。

One hundred and seven smokersreceived randomly either clonidine(n=38),valium(n=34)or placebo(n=35),with at least three sessions of psychoth-erapy.At the end of these treatments,the abstinence rates of the three groupsreached 76.3%,44.1% and 42.8% res-pectively,followed by final rates of 63.2%,41.2% and 40.0% in follow-up ofan average period 4.5 month.Compar-ed with alium nd placebo,clonidineshowed more effect on relieving with-drawal symptoms (P<O.05)and educingdaily consumption (P<O.05).Clonidineis confirmed clinically to help smokingcessation.