精神发育迟滞致病危险因素的调查研究

An investigation on the risk factors of mental retardation in children

本文以济南市两所弱智儿童辅读学校117名精神发育迟滞(MR)患儿作为研究对象,利用1∶1配对的病例对照研究与多因素分析相结合的方法,探讨了致病危险因素。逐步回归分析((α=0.05)揭示 MR 的主要致病危险因素为婴幼期疾病、精神病家族史、母亲孕期毒害因素、母亲文化程度低、出生时家庭人口数多。父亲文化程度低、母亲孕期有精神冲突、新生儿期疾病和异常妊娠。研究结果为该病的综合性防治和有关策略的制定提供了科学依据。

With the purpose of defining the risk factors of mental retardation(MR),a case-control study was carried out in 117 MR children at two special schoolsin Jinan city,compared with an equal number of matched normal controls.In a stepw-ise regression analysis,the risk factors associated with MR were illnesses occurred inthe age of one month to three years,family history of mental disorders,hazardousfactors during pregnncy,neonatal disease,less educated parent,large family at birth,stressful events in pregnancy,and abnormal pregnancy.The results provided someuseful information to the intervention for MR.