可卡因对6-羟基多巴胺所致大脑单侧黑质纹状体系统损伤的大白鼠的旋转行为的影响

THE EFFECTS OF COCAINE ON ROTATIONAL BEHAVIOR IN RATS WITH UNILATERAL LESIONS OF THE NIGROSTRIATAL SYSTEM

本实验观察了Holtzman种系雌性大白鼠34只。以6-OHDA制备单侧大脑黑质纹状体系统损伤的旋转行为模式。在特殊的和自动的球形旋转仪中共进行3次行为观察。以伤侧多巴胺的耗竭率在85％以上,以及具有优势地同侧性的旋转行为的实验动物的实验数据作为分析和讨论的依据。34只雌性大白鼠均符合上述条件。本实验所观察到的盐酸可卡因对动物的旋转行为的影响,其主要结果如下: 可卡因可使实验动物引起刻板的同侧性的旋转行为,其作用迅速。不同剂量的可卡因对动物的旋转行为有不同的影响。 单冷注射可卡因对动物的旋转行为能明显地引起长的至少持续一个星期的促进作用。这就提示,对脑和行为具有持久作用的心理运动的兴奋药,没有必要反复给药。

Thirty-four female albino rats of Holtzman strain were observed in this experiment as models of rotational behavior with unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal system in the brain. Three behavioral observations were conducted in a special and automatic rotometer. Only the data collected on those animals that had more than 85% dopamine depletion at the lesion side and had shown dominantly ipsilateral circling behavior (toward the lesion side) were analyzed and discussed. The 34 female rats all qualified. The effects of cocaine on rotational behavior in rats as observed in this experiment are as follows:It is obvious that cocaine produced a stereotyped and rotational behavior; the action was rapid. Different doses of cocaine produced different effects on rotational behavior in rats.A single exposure to cocaine significantly produced a long-lasting (at least one week) facilitation of rotational behavior in rats. It suggests that it is not necessary to repeatedly administer psychomotor stimulant drugs to produce long-lasting changes in brain and behavior.