“二酮吡嗪学说”的兴亡

Diketopeperazine Theory——Its Rise and Fall

二酮吡嗪学说为一有关蛋白质分子基本结构理论的假说。最初(1923年前后)由苏联有机化学家谢林斯基和萨基柯夫根据一些错误的实验观察提出,后来,以格沃里洛夫为代表的一批支持者又根据一些似是而非的观察和推演,加以发展。当时在苏联它是不同于资本主义国家的见解而得到大力支持。

The so-called Diketopeperazine Theory(DKPT), presented by Soviet scientists, dealt with the primary structure of protein molecules. It originated from a series of blindly erroneous observations and philosophism. In the fifties of this century, this erroneous hypothesis was introduced into China and coercively assigned to be taught in colleges all over the country. As a result, this erroneous theory excluded the correct views on protein molecular structure and obstructed researches and progreses of protein chemistry, biochemistry and biomedical sciences concerned in China. This situation persisted until F. Sanger’s excellent elucidation on polypeptide chain structures of insulin was well-known in our country several years later. From this grave lesson, the author suggests that different academic view-points have to be treated objectively and should never suffer political prejudice.