我国几个民族中毛发根葡糖磷酸变位酶—1的亚型分布

THE DISTRIBUTION OF THE PHOSPHOGLUCOMUTASE-1 (PGM,) SUBTYPES IN SEVERAL CHINESE NATIONALITIES

本文报道了利用等电聚焦的方法,从毛发根鞘细胞分析了我国汉、苗、土家、撒拉、土、达斡尔和赫哲等民族的葡糖磷酸变位酶-1(PGM_1)10亚型的分布,并且与其他人群的基因频率作了比较。

The 10 phenotypes of phosphoglucomutase-l(PGM1) were determined from hair roots in the population sample of Han and six Chinese minorities, i.e., Miao, Tujia, Sala, Tu, Daur and Hoche by isoelectric focusing technies. The frequencies observed for the four alleles in Han population are:PGM11+ = 0.6415, PGM11- = 0.1463, PGM12+=0.1273, PGM12- = 0.0849. And that of the minorities varies: the gene frequencies of 1+ range from 0.7288 in Tujia (Hunan prov.) to 0.5250 in Tu (Qinghai prov.); 1- ranges from 0.2143 in Miao (Hunan prov.) to 0.0254 in Tujia; 2+ ranges from 0.2000 in Tu to 0.0556 in Miao; and 2- ranges from 0.1450 in Tu to 0.0798 in Daur (Heilongjiang prov.). The rare variants (8-al) were found to be as high as 12.5% in Miao, 4.84%, 3.13% and 0.93% in Tujia. Sala and Han respectively, but none was detected from the northeast minorities Daur and Hoche as well as Tu from the northwest. These results were also compared with that of the other races in the world.