损毁海马对大白鼠学习记忆的影响

EFFECTS OF HIPPOCAMPUS DAMAGE ON LEARNING AND MEMORY IN RATS

本实验探讨损毁海马对不同巩固水平的暗箱回避条件反射(DAR)产生的影响,以及损毁海马不同部位对DAR的影响。实验结果表明,广泛地损毁海马使条件反射难于巩固;其次,条件反射愈巩固、所受的影响愈小;第三,条件反射遭受破坏的程度,随海马损毁面积大小和部位不同而不同,海马腹部对DAR的影响重于背部的影响。上述结果证明,海马参予了记忆的各个阶段,而在记忆形成的早期阶段则更为重要,海马腹部和背部参予程度有一定差异。

In this paper the effects of hippocampus damage on the different stagesof the establishment of dark avoidence conditioned reflex (DAR) and theinfluences of different parts of hippocampus on DAR were reported. The Dataof our experiments were as follows: 1. The extensive damage of thehippocampus results in difficulty to consolidate The DAR, and the more theconditioned reflex is consolidated, the less it is interfered by the extension; 2.The influence of hippocampus on the DAR depends on the region and theextension of damage, and the effect of ventral hippocampus damage on theDAR is more prominent than that of the dorsal one. The results demonstratedthat the hippocampus takes part in the different stages of memory, especiallythe early stage, and the effects of different parts of the hippocampus aredifferent.