慢性肺心病急性期凝血谱的变化

The clinical observation of blood coagulation function in patients with chronic cor pulmonale during acute attack

目的 观察 6 1例肺心病急性期患者凝血谱的变化。方法 将研究对象分为肺心病急性期组 (6 1例 )和对照组 (5 5例 ) ,并且将肺心病急性期组分成轻、中、重三小组 ,分别测定凝血酶时间 (TT)、凝血酶原时间 (PT)、部分凝血活酶时间 (APTT)、纤维蛋白原 (Fbg)、凝血酶原比值 (PT/R)。结果 肺心病患者TT、PT、APTT、PT/R均显著低于对照组 (P <0 .0 5或P <0 .0 1) ,并随病情加重而显著下降倾向 (P <0 .0 1) ;Fbg高于对照组 (P <0 0 1) ,并随病情加重而显著升高 (P <0 .0 1)。结论 慢性肺心病急性期患者的血液呈高凝状态 ,并与病情轻重有相关性。

Objective To observe the changes of the trombina(coagulation) function in patients with cor pulmonale during acute stage.Methads 61 cases with cor pulmonale during acute stage were divided into three groups according to their disease course: the severe, moderate and mild group and 55 healthy cases were collected as control. Thrombin time (TT), prothrombin time (PT), prothrombin ratio(PT/R), content of fibrinogen (Fbg) and activated partial thromboplastin time(APTT) were measured in all samples.Results Data of the TT, PT, APTT and PT/R in patients with the cor pulmonale were lower than those in the control group (P<0.01 P<0.005), and each data decreased when state of illness became severe, whereas, the Fbg content was higher than that of control group and increased when state of illness became severe.Conclusion The bloods of patients with the cor pulmonale during acute stage were in hyper coagulation state that was related to severity of disease. Recognizing and correcting the changes were helpful to reduce the fatality rate.