玻璃体内注射t-PA和C_3F_8治疗黄斑部视网膜下出血的临床研究

INTRAVITREOUS INJECTION OF t-PA AND GAS OF C_3F_8 TO TREAT RETINAL SUBMACULAR HEMORRHAGE

目的 研究组织型纤溶酶原激活剂 (t PA)和过氟丙烷 (C3 F8)玻璃体内注射治疗黄斑部视网膜下出血的临床效果。方法 黄斑部视网膜下出血 5 1例 5 1只眼 ,随机分为 4组 ,A组 :空白对照组 ;B组 :t PA和C3 F8治疗组 ;C组 :t PA治疗组 ;D组 :C3 F8治疗组。t PA和C3 F8注射量分别 2 5 μg(0 .1ml)和 0 .3ml。 结果 治疗后10d :各组出血吸收无统计学意义 (P >0 .0 5 ) ;治疗后 1、3个月 :各组出血吸收有显著性差异 (χ2 =15 .74 ,16 .79;P <0 .0 5 ) ,B组优于其他各组。治疗前、后裸眼视力比较仅B组差异有显著性意义 (F =13.5 3,P <0 .0 1)。未见并发症。结论 t PA联合C3 F8玻璃体内注射治疗黄斑部视网膜下出血是一种简便、安全、有效的方法。

Objective To explore the clinical effects of injection of tissue plasminogen activator (t-PA) and gas of C 3F 8 to treat retinal submacular hemorrhage.Methods 51 eyes of retinal submacular hemorrhage were randomly divided into Group A(the contrast group),Group B treated with t-PA and C 3F 8,Group C treated with t-PA and Group D treated with C 3F 8.The injection doses of t-PA and C 3F 8 were 25ug(0.1ml) and 0.3ml respectively.Results 10 days of treatments showed no statistical significance in terms of the absorption of hemmorrhage(P>0.05).All groups showed significant differences one and three monther later (χ 2=15.74, 16.79;P<0.05).The Best curative effects were got in Group B.Only Group B got obvious improvement in visal acuity after treatment(F=13.53,P<0.01) and complications occurreol.Conclusion Intravitreous injection of t-PA and C 3F 8 can be used effectively to treat retinal submacular hemorrhage.