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和营安心方抗心肌细胞氧化应激作用及对心肌细胞内钙离子的影响 被引量:2

Protective Effects of He Ying An Xin Fang on Free Radical Injury Induced by H2O2 in Myocardium Rats
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摘要 目的探讨和营安心方抗心肌细胞氧化应激作用和对心肌细胞内钙离子的影响。方法用低浓度(200μmol·L-1)过氧化氢(H2O2)模拟缺血再灌注心肌细胞的氧化应激状态,大鼠心肌细胞分为正常对照组、模型组、和营安心方高(500mg·kg-1)、中(250mg·kg-1)、低(125mg·kg-1)三个剂量组,分别测定各组细胞培养液中过氧化氢酶(CAT)和超氧化物歧化酶(SOD)的含量,并测定心肌细胞钙离子的含量。结果和营安心方可以显著性提高心肌细胞CAT和SOD含量(P<0.05),并且可以显著降低心肌细胞内钙离子的浓度,相对于模型组差异有显著性(P<0.05)。结论和营安心方对心肌细胞有很好地保护作用,其作用机制可能与抗过氧化氢氧化应激损伤有关,和营安心方还能够显著降低钙离子浓度。
出处 《河北北方学院学报(自然科学版)》 2014年第1期84-86,共3页 Journal of Hebei North University:Natural Science Edition
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