摘要
由于贵金属纳米粒子独特的光学性质,基于衬底的贵金属纳米粒子薄膜表面增强拉曼散射技术在分子生物学和医学免疫分析等研究领域中显现出非常好的应用优势和潜力。本项研究工作应用柠檬酸纳作聚集剂诱导水溶液中对巯基苯甲酸修饰的Ag纳米粒子聚集,并应用以此形成的"热点"增强SERS光谱,获得了对巯基苯甲酸修饰的Ag纳米粒子聚集非常有效的4-MBA分子的SERS信号,为未来建立生物待测物的分析检测奠定前期基础。结果证明,水溶液中的Ag纳米粒子的聚集形成的"热点"具有非常好的SERS光谱增强效应。
Technology of surface enhanced Raman scattering (SERS) on substrate based on film of noble metal nanoparticles has many advantages of application and potentiality in molecular biology, immunoassay of medicine and organic molecules, etc. In this work, in order to research SERS, sodium citrate was employed as aggregation reagent to induce the aggregation of Ag nanoparticles modified by 4-mercaptobenzoic acid. And the 'hot spots' resulted from the aggregation were used to enhance the SERS spectra. Strong SERS spectra of 4-mercaptobenzoic acid molecules were observed. In conclusion, 'hot spots' of aggregation of Ag nanoparticles modified by 4-mercaptobenzoic acid in aqueous solution has highly effect of SERS.
出处
《发光学报》
EI
CAS
CSCD
北大核心
2014年第2期263-267,共5页
Chinese Journal of Luminescence
基金
国家自然科学基金(61071048
11374297
51372096)资助项目
关键词
银纳米粒子聚集
水溶液
热点
SERS光谱
Molecular biology
Molecules
Nanoparticles
Raman scattering
Raman spectroscopy
Solutions
Substrates
Surface scattering
