摘要
辐射可以诱导受照细胞及子代基因组不稳定性的发生。基因组不稳定性导致基因的突变率增加,并通过多种机制致癌。本文简要介绍了基因组不稳定性的可能机制,及其在辐射致癌中的作用。
Ionizing radiation induces genomic stability ,which is transmitted over many generations after irra-diation .Since induced genomic instability accumulates gene mutations ,it has been thought to play a role in ra-diation-induced carcinogenesis .Understanding the mechanism of genomic instability will provide unique oppor-tunities to identify new diagnosis and therapeutic targets . This review focuses on recent discoveries on the mechanisms governing the formation of genomic instability .
出处
《辐射防护通讯》
2014年第2期24-27,共4页
Radiation Protection Bulletin
关键词
基因组不稳定性
辐射致癌
机制
Genomic instability
Radiation-induced carcinogenesis
Mechanism
