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脂代谢紊乱与2型糖尿病肾病关系的研究 被引量:1

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摘要 脂代谢紊乱既是许多原发性和继发肾脏病常见临床表现,又参与肾脏病的发展,是肾小球硬化发生、发展的独立因素.脂代谢紊乱是糖尿病患者常见并发症之一,其不仅与大血管并发症密切相关且与微血管病相关,尤其低密度脂蛋白胆固醇(LDL)和载脂蛋白A(ApoA)在糖尿病性肾病(DN)发生发展中起重要作用.对氧磷酯酶-1(PON1)是一类与高密度脂蛋白胆固醇(HDL)紧密结合的芳香酯酸,晚近研究证实,其与LDL代谢密切相关,可减少氧化低密度脂蛋白堆积,减轻微血管损害.我们对各组PON1活性血脂测定探讨其在DN发生、发展中的作用.
出处 《中国煤炭工业医学杂志》 2004年第9期826-827,共2页 Chinese Journal of Coal Industry Medicine
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  • 1Ha H, Roh DD, Kirschenbaum MA, et al. Atherogenic lipoproteins enhance mesangial cell expression of platelet - derived growth factor: Role of protein tyrosine kinase and cyclic AMPdependent puotein dinase A[J ]. J Lab Clin Med, 1998,131: 456-465
  • 2Moorhead J,Chan MK, El- Nahas M, et al. Lipid nephrojtoxicity in chronic progressive glomerular and tubulo- interstitial disease[J]. Lancet, 1982,2(8311 ): 1309-1311
  • 3Al - Shebeb T, Frohlich J, Magil AB. Glomerular disease in hypercholesterolemic guinea pigs: a pathogenetic study[J ]. Kidney Int Suppl, 1998,33 (2): 498-507
  • 4Rovin BH, Tan LC, LDL stimulates mesangial fibronectin production and chemoattractyant expression[J ]. Kidney Int, 1993,43: 218-225
  • 5Greiber S, Kreusel M, Pavenstadt M,et al. Lipoprotien(a) induces glomerular superoxdie anion produetion[J ]. Nephrol Dial Transplant, 1997,12(7): 1330-1335
  • 6Wanner C, Greiber S, Kramer- Guth A, et al. Lipids and progression of renal diseases:role of modified low density lipoprotein nd lipoprotein[J ]. Kidney Int Suppl, 1997, 63: S102-106
  • 7Moorhead J F. Lipids and progressive kidney disease [ J ]. Didney Int Suppl, 1991,31 :s35-40
  • 8Keane WF. The role of lipids in renal desease: future challenges[J]. Kidney Int Suppl,2000,57(75): 14S27-31
  • 9Attman PO,Alaupovic P,Ssmuelsson O. Lipoprotein abnormalities as a risk factor for progressive nondiabetic renal disease[J ].Kidney Int Suppl, 1999,71: S14-17
  • 10Fogo AB. Progression and potential regression of glomerulosclerosis. Kidney Int ,2001,59(2) :804-819

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