某院住院孕产妇超说明书用药调查

Off-label Drug Use in obstetrics and gynecology ward

目的:回顾性调查石河子大学医学院第一附属医院住院孕产妇超说明书用药情况,及时反馈临床以促进本院孕产妇合理用药。方法:收集本院2013年1月1日至10月31日妇产科住院孕产妇的用药医嘱,依据药品说明书,分别对医嘱中的适应证、人群适宜性、给药剂量、频次、溶媒等方面进行系统分析。结果:共抽取住院孕产妇1 026例,分析用药医嘱17 407条,涉及药品147种;按照患者、用药医嘱和药品计,超说明书发生率分别为68.42%、10.59%和8.84%。超说明书用药类型中超用法、用量所占比例最大,达到了62.73%。排名前4位的超说明书用药种类依次为激素及其有关药物(35.53%)、呼吸系统药物(28.05%)、血液及造血系统药物(24.78%)和调节水、电解质和酸碱平衡药物(23.35%)。结论:通过本文的调查,发现本院的住院孕产妇超说明书用药的现象时有发生。建议医生临床用药时注意权衡利弊,尽量按照药品说明书中规定的要求使用药物。确有需要超说明书用药时应以充分的循证医学证据支持为前提,从而避免医疗纠纷和执业风险。

Objective:To determine the extent of off-label drug use in obstetrics and gynecology ward of Shihezi Uni-versity hospital from January 1,2013 to October 31,2013,In order to promote rational drug use in pregnant and parturient women.Methods:Collected from January 1,2013 to October 31 in the hospital of obstetrics and Gynecology ward medicationorders,based on the drug package insert,indications on doctor''s orders,respectively,groups of suitability,dose,frequency,solvent for analysis,determine whether its Off-label Drug Use as well as Off-label Drug Use types and analysis of key hyper -Manual of evidence-based medicine proofs.Results:The total 1026 pregnant and parturient women were selected ,and 17407The rate of off-label drug use was 68.42%,10.59% and 8.84% in pregnant and parturient women,medication orders anddrug categories,respectively.prescriptions involving 147 drugs were analyzed.Off-label Drug Use the largest proportion typeSuper-usage,dosage,reached a total of 62.73%.The top four Types of drugs off-label drug use is Regulation of water ,electrolyteand acid-base balance of drugs,hormones and related drugs,central nervous system drugs and blood and blood-formingsystem drugs.Conclusion:The off-label drug use in obstetrics and gynecology ward is common in Shihezi UniversityHospital and Most of which are supported by Clinical evidence ;But due to lack of evidence of more authoritative evidence -based medicine.So the doctor for pregnant and parturient women clinical off -label drug should be weighed.