营养干预对鼻咽癌患者放化疗疗效的影响

Influence of Nutritional Intervention on The Efficacy of Chemoradiotherapy for Nasopharyngeal Carcinoma

目的探讨营养干预对鼻咽癌患者放化疗疗效的影响。方法将86例鼻咽癌放化疗患者随机分为营养干预组和对照组。营养干预组患者在放化疗过程中给予营养干预,而对照组则按照临床常规方式处理。比较2组患者的放化疗疗效、不良反应发生情况和放化疗前、后营养学指标的变化。结论营养干预组患者化疗有效率为95.3%,显著高于对照组有效率74.4%;在不良反应方面,营养干预组Ⅲ和Ⅳ级口腔黏膜损害明显低于对照组,P值分别为0.028和0.012。放化疗结束时,营养干预组的营养学指标优于对照组。结论营养干预能够保证鼻咽癌患者对放化疗的依从性,有利于提高临床疗效。

Objective To explore the influence of nutritional intervention on the efficacy of chemoradiotherapy for naso -pharyngeal carcinoma .Methods 86 patients with nasopharyngeal carcinoma who underwent chemoradiotherapy were randomly divided into the nutritional intervention group and the control group .The nutritional intervention group were given the nutritiona 1 interventions during chemoradiotherapy ,while the control group were subjected to clinical routine treatments .Curative efficacies , adverse reactions and the changes of the nutritional indexes before and after chemoradiotherapy of the 2 groups were compared . Results Effective rates of the nutritional intervention group and the control group were 95.3% and 74.4%,respectively.Re-garding adverse reactions ,stage Ⅲ and Ⅳ oralmucosa damages of the nutritional intervention group were markedly lower than those of the control group(P=0.028 and P=0.012).After chemoradiotherapy,the nutritiona1 indexes of the nutritional interven-tion group were superior to those of the control group (P<0.05).Conclusion Nutritional intervention can improve the compli-ance of nasopharyngeal cancer patients to chemoradiotherapy and improve clinical efficacy .