老年急性髓系白血病标准化疗的临床观察

Clinical Observation of Standard Chemotherapy for Elderly Patients with Acute Myeloid Leukemia

目的：探讨老年急性髓系白血病标准化疗方案的治疗效果。方法将120例老年AML患者按照年龄分为65～70岁患者组（ A组）和＞70岁患者组（ B组），比较不同年龄阶段患者在标准化疗下的缓解率、早期死亡率、诱导期死亡率、不良事件的发生率、中位生存期及5年生存期。结果 A组缓解率大于B组，不良事件的发生率低于B组，差异均有统计学意义（P＜0．05）。2组患者早期死亡率、诱导期死亡率、中位生存期及5年无病生存率比较，差异无统计学意义（P＞0．05）。结论＞70岁患者亦可接受标准化疗，老年白血病的治疗应遵循个体化原则。

Objective To study the efficacy of standard chemotherapy for elderly patients with acute leukemia (AML). Methods 120 cases of elderly patients with AML were divided into group A with patients who were 65-69,and group B with pa-tients who were over 70.Remission rates,early death rates,inductive phase mortality rates ,incidence of adverse events ,median survival time and 5-year disease-free survival of the 2 groups were compared .Results Remission rate of the group A was higher than that of the group B ,and incidence of adverse events of the group A was lower than that of the group B .There had statistical difference(P<0.05).Early death rates,inductive phase mortality rates,median survival time and 5-year disease-free survival of the 2 groups had no statistical difference (P>0.05).Conclusion Patients who are over 70 can receive standard chemotherapy , and the treatment for elderly patients with AML should follow individualized chemotherapy .