子宫颈癌新辅助化疗不同给药途径对疗效的影响

Clinical Efficacy of 2 Different Regimens of Neoadjuvant Chemotherapy for Cervical Carcinoma

目的探讨子宫颈癌新辅助化疗不同给药途径对疗效的影响。方法将118例ⅠB2-ⅡB期根治术前行新辅助化疗的宫颈癌患者分为子宫动脉灌注栓塞新辅助化疗组(动脉组)、静脉新辅助化疗组(静脉组),并比较2组间的疗效及不良反应。结果肿瘤消退有效率动脉组为86.0%,静脉组为70.6%,差异有统计学意义(P<0.05)。动脉组和静脉组在手术所花时间方面差异无统计学意义(P>0.05),但2组术中出血量比较,动脉组出血量明显低于静脉组(P<0.05),在宫旁浸润和脉管癌栓的发生率方面动脉组也明显低于静脉化疗组(P<0.05),消化道反应及骨髓抑制发生率动脉组明显低于静脉组,差异有统计学意义(P<0.05)。结论子宫动脉灌注栓塞化疗近期效果明显优于静脉化疗,并且消化道反应小、骨髓抑制发生率低。

Objective To study the clinical efficacy of 2 different regimens of neoadjuvant chemotherapy for cervical car-cinoma.Methods 118 stage ⅠB2-ⅡB cervical carcinoma patients were divided into the intra-arterial infusion chemoemboliza-tion group ( arterial group ) and the venous chemotherapy group ( venous group ) .The efficacy and adverse reactions of the 2 groups were analyzed and compared .Results The tumor reduction rates of the arterial group and the venous group were 86.0% and 70.6%,respectively.The difference was statistically significant (P<0.05).The difference of the operation time between the 2 groups was not statistically significant(P>0.05).The operative blood loss of the arterial group was significantly lower than that of the venous group(P<0.05).The incidence rate of parametrial infiltration and vascular tumor thrombus of the arterial group was significantly lower than that of the venous group (P<0.05).The incidence rates of gastrointestinal reaction and bone marrow inhi-bition of the arterial group was significantly lower than that of the venous group (P<0.05).Conclusion The short-term curative effect of intra-arterial infusion chemoembolization is better than venous chemotherapy for cervical carcinoma , and the incidence rate of gastrointestinal reaction and bone marrow inhibition is obviously lower in the arterial group .