丹参多酚酸盐对冠心病心力衰竭患者左心功能及血清心型脂肪酸结合蛋白的影响

Influence of salvianolate on cardiac function and content of H-FABP in patients with coronary heart disease and heart failure

目的探讨丹参多酚酸盐对冠心病心力衰竭患者能及血清心型脂肪酸结合蛋白(H-FABP)的影响。方法选择冠心病心力衰竭患者120例,随机分为治疗组和对照组各60例。对照组按心血管指南常规治疗。丹参多酚盐组在此治疗基础上加用丹参多酚酸盐200 mg+5%葡萄糖注射液静脉滴注,每日一次,14 d为一个疗程。所有患者治疗前及治疗后6个月采用超声心动图评价心脏收缩功能的改善情况,治疗6 w后比较两组患者心功能及血清H-FABP。结果治疗后两组心输出量(CO)、心脏指数(CI)、每搏量(SV)、左室射血分数(LVEF)均较治疗前有改善,治疗组改善的程度优于对照组(P<0.05);疗后治疗组脑钠肽(BNP)、血清H-FABP水平低于对照组(P<0.05,P<0.01),治疗后治疗组临床疗效优于对照组(P<0.05)。结论丹参多酚酸盐能显著改善患者左心功能及降低其血清H-FABP水平。

Objective To explore the curative effect of salvianolate on patients with coronary heart disease and heart failure ( CHF) . Methods A total of 120 CHF patients with heart failure were randomly divided into two groups ,one was routine treatment group: treated with routine therapy , another was salvianolate treatment group:treated with salvianolate on the basis of above routine treatment .All the pa-tients were followed up for 6 months to observe the changes of the clinical symptoms ,left ventricular ejection fraction ( LVEF) ,CO/SV, and paroxysm count of myocardial ischemia within 24 h.Results After treated for 6 months,the total therapeutic effect of treatment group was 91.7%,LVEF and CO/SV were significantly increased , the H-FABP and BNP level of CHF patients and heart failure were decreased ( all P<0.05 ) .Above indexes changes in treatment were more than those of routine therapy group ( all P<0.05 ) .Conclusions Salvianolate could be the effective drug used for treating CHF .