青光眼与帕金森病的相关性

The relationship of primary close-angle glaucoma and Parkinson's disease

目的探讨原发性闭角性青光眼(PACG)患者帕金森病(PD)发病率及其关联性。方法对320例青光眼患者进行帕金森病筛查,选择年龄、性别等人口学情况相匹配的健康对照者320例作为对照,分析并比较两组患者PD检出情况,分析青光眼与PD的相关性。结果 PACG患者中伴PD 33例(10.3%),对照组PD患者23例(7.2%)。两组在各年龄段PD发生率比较差异均无统计学意义(均P>0.05)。单因素及多因素分析提示青光眼病程、严重程度与MMSE评分呈负相关(P<0.05),与年龄、PD病程、PD严重程度成正相关(P<0.05),与性别、PD临床类型、PD家族史无相关性(P>0.05)。结论 PACG可能与PD的发生率存在一定关系,临床监测和控制青光眼病情可为PD的早期防治提供临床依据。

Objective To discuss the relationship between primary close-angle glaucoma (PACG) and Parkinson's disease (PD). Meth ods 320 PACG patients(group A) and 320 cases of non-glaucoma controls (group B)were investigated with 1 ∶1 matched cases-con-trol study.The relationship of PACG and PD in both subjects was detected and compared the detective rate.Results There were 33 (10.3%) PD patients in group A and 23 (7.2%)PD patients in group B .There was no significant difference in the detection rate of PD in different ages between two groups ( P>0.05) .Logistic analysis results showed PACG history and severity were positive correlation with age ,PD history and PD severity ( P<0.05 ) ,and negative correlated with MMSE (P <0.05 ).There were no correlated with sex ,clinical type and family history ( P>0.05 ).Conclus ions PACG is possibly correlated to PD ratio.To monitor and control the condition of glaucoma could provide a clinical basis for preventing and treating PD.