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Foxq1与E-cadherin蛋白在大肠癌中的表达及其临床意义 被引量：6

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摘要 目的探讨Foxq1与E-cadherin在大肠癌中的表达及其与大肠癌发病和转移的临床病理关系。方法收集大肠癌的临床病理标本62例,采用免疫组织化学法和Western印迹检测Foxq1与E-cadherin蛋白在标本中的定位与表达水平。结果 Foxq1与E-cadherin蛋白均在细胞质中表达,Foxq1表达在癌组织、癌旁组织、正常黏膜组织中梯度降低;E-cadherin表达在癌组织、癌旁组织及正常膜组织居中梯度升高(P<0.05)。二者的表达在大肠癌中呈负相关(P<0.05)。结论 Foxq1和E-cadherin参与了大肠癌的发病,可作为大肠癌早期诊断的联合指标之一,并且为大肠癌的治疗提供新靶点。
作者 骆赞 魏正强 向相 蒙长远 黎晖 汤为学
机构地区 重庆医科大学附属第一医院胃肠外科 重庆市神经病学重点实验室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第8期2076-2078,共3页 Chinese Journal of Gerontology
关键词 Foxq1 E-CADHERIN 大肠癌 转移 相互作用
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献9

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二级参考文献82

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共引文献48

同被引文献98

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引证文献6

二级引证文献18

中国老年学杂志
2014年 第8期

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