紧张型头痛患者导水管平面脑脊液流动相位对比法磁共振成像研究

Phase contrast magnetic resonance imaging of cerebrospinal fluid flow through the aqueduct of sylvius in chronic tension-type headache

目的:研究紧张型头痛患者导水管平面脑脊液流动特点。方法:紧张型头痛患者17例,正常对照者26例,在导水管平面应用相位对比法脑脊液磁共振流动分析序列进行扫描,扫描数据应用脑脊液流动分析软件进行定性观察和定量测量。结果:头痛组与对照组导水管平面脑脊液均呈与心脏博动相关的双向节律性流动。对照组脑脊液流动曲线平滑"U"型25例、波浪型1例;头痛组脑脊液流动曲线平滑"U"型11例,波浪型6例(P<0.05)。对照组与头痛组导水管平面头侧方向脑脊液流量分别为(0.235±0.157),(0.133±0.106)mL/s(P<0.05),流速分别为(6.023±2.654),(3.479±2.364)cm/s(P<0.05);足侧方向脑脊液流量分别为(-0.358±0.201),(-0.190±0.141)mL/s(P<0.05),流速分别为(-8.263±3.020),(-4.788±2.862)cm/s(P<0.05)。结论:头痛组导水管平面脑脊液流动曲线、头侧及足侧方向脑脊液平均流量、流速与对照组比较均有明显差异,相位对比法磁共振成像显示慢性紧张型头痛患者脑脊液流动异常。

Objective: To study the cerebrospinal fluid(CSF) flow through the aqueduct of sylvius in chronic tension-type headache patients with phase contrast magnetic resonance imaging. Methods: Phase contrast magnetic resonance imaging(MRI) of the CSF flow through the aqueduct was obtained from 17 patients with chronic tension-type headache and 26 control subjects. A software for CSF flow was applied for MRI data analysis both qualitatively and quantitatively. Results: h e CSF through the aqueduct l ew in the caudal and cranial directions with the rhythm of the heartbeat in both groups. h ere were 2 types of l ow curves: the smooth 'U' and the wave,which were 25 vs 1 in the controls and 11 vs 6 in the patients(P<0.05), respectively. The mean caudocranial flow rate through the aqueduct was(0.235±0.157) mL/s vs(0.133±0.106) mL/s(P<0.05) and the velocity was(6.023±2.654) cm/s vs(3.479±2.364) cm/s(P<0.05), and the mean craniocaudal l ow rate was(-0.358±0.201) mL/s vs(-0.190±0.141) mL/s(P<0.05) and the velocity was(-8.263±3.020) cm/s vs(-4.788±2.862) cm/s(P<0.05), respectively. Conclusion: The CSF flow curve, rate and velocity through the aqueduct in the patients with chronic tension-type headache is anomalous in comparison with the controls.