脂肪干细胞在肌腱组织工程中的研究进展

Advance of adipose-derived stem cells in tendon tissue engineering

严重的肌腱缺损带来严重的社会及经济负担,传统治疗方法效果欠佳。肌腱组织工程为治疗严重的肌腱缺损提供了新的方向。脂肪干细胞较骨髓干细胞有来源广泛,分离过程简单、安全等优点,具有向多种细胞分化的潜能及强大的自我增殖能力。脂肪干细胞在生长因子、周期性张力及氧分压等适宜刺激下可分化为肌腱细胞,分泌肌腱细胞外基质,形成组织化工程肌腱以修复严重缺损的肌腱,改善因肌腱缺损导致的功能障碍。

Tendon tissue engineering is a novel therapeutic strategy for severe tendon injury and loss. Adiposederived stem cells(ASCs) have been studied extensively, due to their potency to dif erentiate into musculoskeletal tissue precursors such as osteoblasts, chondrocytes, adipocytes, and tendocytes under specii c cues and high ability of proliferation. Resources of ASCs are ubiquitous and isolation of ASCs is secure, simple and minimally invasive. Mounting evidences demonstrate that ASCs may be involved in tendon tissue engineering and repair the severe injury of tendon under stimulation of various growth factors and other appropriate i t ings.