摘要
胆囊癌是最常见的胆道系统恶性肿瘤,预后非常差。流行病学资料显示胆囊癌与胆囊结石以及其他原因导致的胆囊慢性炎症状态密切相关。慢性炎症导致胆囊癌发生发展的机制也成为了近年研究的热点,持续的局部炎症反应可能通过刺激细胞生长、抑制细胞凋亡,诱导血管生成和削弱免疫反应来促进突变细胞的生长和增殖能力、促进肿瘤细胞的侵袭和转移能力。
Gallbladder cancer(GBC) is the most common biliary tract malignancy with an extremely poor prognosis. Epidemiological data have demonstrated that chronic inflammation resulting from infection of gallbladder or gallstones predispose individuals to GBC. Recent studies have begun to elucidate molecular mechanisms underlying the development of GBC in the setting of chronic inflammation. It is possible that persistently local inflammatory reactions may contribute to the development and progression of GBC through inducing genetic alterations,and subsequently promoting survival and proliferation of mutated cells,inhibiting apoptosis,stimulating angiogenesis and metastasis.
出处
《外科研究与新技术》
2014年第2期79-81,共3页
Surgical Research and New Technique
关键词
胆囊癌
慢性胆囊炎
胆囊结石
Gallbladder cancer
Chronic inflammation
Gallstones
