摘要
大黄酚是中药大黄主要的有效单体之一,属于蒽醌类化合物。研究表明,大黄酚在脑缺血再灌注损伤、阿尔茨海默病中表现出很好的神经保护作用,其机制可能包括:抗氧化,抑制组织中乙酰胆碱酯酶(acetylcholine sterase,AChE)活性,调节脑内氨基酸水平,增强脑组织耐缺氧能力,减轻海马神经元损伤,抑制神经元凋亡等。大黄酚是一种具有广阔应用前景的化合物,该文对大黄酚近年来神经保护作用研究进展作一综述。
Chrysophanol is an active component of the herbal medicine rhubarb (Rheum palmatum). Many researches have shown that chrysophanol has extensive bioactivity in cerebral ischemia-reperfusion injury and Alzheimer’s disease. The neuroprotective mechanisms include antioxidant, AChE activity inhibition, brain amino acid modulation, brain tissue hypoxia tolerance enhancement, hippocampal neuron damage protection and neuronal apoptosis inhibition. It is a compound with a broad application potential. This paper mainly discussed the protective effects and mechanisms of chrysophanol in the nervous system.
出处
《神经药理学报》
2014年第1期52-57,共6页
Acta Neuropharmacologica
基金
河北北方学院重大项目(No.ZD201310)
河北省青年科学基金项目(No.H2014405031)
关键词
大黄酚
抗氧化
脑缺血再灌注
神经元凋亡
chrysophanol
antioxidant
cerebral ischemia-reperfusion
neuronal apoptosis
