新城疫病毒样颗粒研究进展

Progress of Newcastle Disease Virus-like Particles

病毒样颗粒(virus-like particles,VLPs)是指利用异源宿主系统表达的病毒结构蛋白自行组装成不含病毒基因组、不能复制、不具有感染能力的病毒样蛋白颗粒。VLPs具备构想逼真、安全、稳定、可刺激体液和细胞免疫应答、作为载体表达其他抗原以及可设计成区分自然感染与免疫接种等诸多优点。这些优点使得VLPs在过去30年中成为新一代疫苗制备平台。作者就新城疫VLPs相关研究进展进行较为详尽的综述,以期为中国新城疫VLPs的研究提供参考。

Virus-like particles(VLPs)refers to the virus structural protein self assembling into particles without virus gneome by using heterologous host system.It can't copy and does not have the infection ability.VLPs combine many of the advantages,such as,well-defined geometry,safety,high stability,inducing strong humoral and cellular immune responses,applicability as vectors for the presentation of foreign antigens and amenable to fulfil the Differentiating Infected from Vaccinated Animals(DIVA).On behalf of above advantages,over the last three decades,VLPs have evolved to become a widely accepted new technology in the field of vaccinology.Here,in order to provide reference to the research of Newcastle disease VLPs,we review the current status of Newcastle disease VLPs to provid a guidelines for us to study the Newcastle disease VLPs in the future.