绝经后女性血清网膜素-1与骨密度的关系

Serum omentin-1 concentration and bone mineral density in postmenopausal women

目的:探讨绝经后女性血清网膜素-1浓度与骨密度的关系,进一步了解脂肪组织对骨密度的影响。方法:运用双能X线骨扫描仪(DEXA)测定此336名受试人群全身总体骨密度、腰椎正位、左侧前臂、髋部总体、左侧股骨颈、Ward’s三角区、左侧股骨大转子及转子内骨密度及体成份,运用酶联免疫吸附试验(ELISA)测定血清脂肪因子(网膜素,脂联素,瘦素,抵抗素,内脏脂肪素,apelin)浓度。结果:超重及肥胖组较正常体重组有更高的总髋、股骨颈、转子内骨密度;血清网膜素-1与腰椎、股骨颈、股骨大转子、转子内、总髋、Ward’s三角区BMD呈负相关(r=-0.159,-0.259,-0.233,-0.243,-0.247,-0.112),校正年龄、BMI及体脂后,网膜素-1与各部位BMD相关无显著性。逐步多元线性回归分析,总瘦重、绝经年限及雌激素是总体及各部位骨密度的独立相关因素,其变化分别可以解释12.2%~13.7%,6.9%~13.1%,0.9%~1.7%的变异。血清脂联素是腰椎、总髋及总体骨密度的独立相关因素。结论:绝经后女性血清网膜素-1与各部位及总体骨密度无显著相关;雌激素、绝经年限、瘦重是绝经后女性各部位及总体骨密度的独立预测因子。血清脂联素是腰椎、总髋及总体骨密度的独立预测因子。

Objective: To determine the relationship between serum omentin-1 concentration and bone mineral desity in postmenopausal women, and the adipose influence of tissue on bone mineral density (BMD). Methods: BMD values of 336 participants were measured by dual-energy-x-ray absorptiometry (DEXA) at various skeletal sites: the anteroposterior spine, femeral neck, total hip (T-hip) and total body BMD (TBMD). Body compositions including lean tissue mass (LTM) and body fat mass (FBM) were measured by DEXA. hTe plasma concentrations of adipocytokines (omentin-1, adiponectin,leptin,resistin,visfatin, andapelin) were measured by ELISA. Results: hTe overweight and obese groups had higher T-hip,femerol neck, intertrochanter BMDthan the nomal weight group. Plasma omentin-1 was negatively correlated with anteroposterior spine, femeral neck, trochanter, intertrochanter, T-hip and Ward’s BMD, after adjustment for age, BMI and fat body mass, and the correlation was not significant. Multiple stepwise regression anlysis revealed that lean body mass, menopause duration and estrogen level were the most important variables affecting the BMD and each explained 12.2%–13.7%, 6.9%–13.1%, 0.9%–1.7% of the variance. Serum adiponectin was independently associated with T-hip, lumbar spine and total BMD. Conclusion: Plasma omentin-1 is not significantly correlated with BMD in postmenopausal women. Lean body mass, menopause duration and estrogen level are the most important variables affecting the BMD. Serum adiponectin is an independent predictor of T-hip, lumbar spine and total BMD.