术前吸烟对食管鳞癌患者生存期的影响

Infl uence of Preoperative Smoking on Survival of Patients with Esophageal Squamous Cell Carcinoma

目的探讨术前吸烟对食管鳞癌生存期的影响。方法通过问卷调查、电话随访和住院病理结果核查。采用t检验和Spearman相关分析吸烟与食管鳞癌发生的关系,Kaplan-Meier生存曲线、Log rank检验、Cox回归评估影响患者生存期的独立因素。结果吸烟患者平均发病年龄明显高于不吸烟患者(P=0.02),开始吸烟年龄与发病年龄呈正相关(r=0.474,P<0.001);不吸烟患者的生存期优于吸烟患者(P<0.001),然而男性吸烟与不吸烟患者的生存期差异无统计学意义(P=0.245),并且不吸烟患者中女性患者的生存期明显优于男性(P<0.001);Cox回归分析提示吸烟不是影响食管鳞癌患者生存期的独立因素。结论食管鳞癌患者发病年龄与开始吸烟年龄高度相关;术前吸烟对食管鳞癌患者的生存期无明显影响。

Objective To investigate the impact of preoperative smoking on survival of the patients with esophageal squamous cell carcinoma(ESCC).Methods Based on the questionnaire, telephone follow-up and hospital pathological records, t-test and Spearman correlation analysis were used to analyze the relationship between smoking and ESCC survival. Kaplan-Meier analysis, Log rank test and Cox regression analysis were applied to analyze the independent risk factors for survival.Results The mean onset age of smoking patients was signifi cantly higher than that of non-smoking patients(P=0.02). The onset age of ESCC was positively correlated with the age of initial smoking(r=0.474,P<0.001). The survival time of non-smoking patients was apparently longer than that of smoking patients(P<0.001). However, there was no difference in male patients no matter smoking status(P=0.245). Moreover, the survival time in non-smoking female patients was signifi cantly longer,compared to non-smoking male(P<0.001). Cox regression analysis showed that preoperative smoking was not the independent factors for ESCC survival. Conclusion The onset age of ESCC patients was highly correlated with the age of initial smoking and preoperative smoking had no impact on the prognosis of ESCC.