前列腺癌患者骨转移的血清学证据研究进展

Serologic Evidence in Early Detection of Bone Metastasis in Patients with Prostate Cancer

我国的前列腺癌患者在初次诊断时即有较高比例的骨转移,所以在前列腺癌患者中早期筛查骨转移尤为重要,无论对于制定有效的治疗方案还是预后评估都具有重要的临床价值。放射性核素全身骨显像对前列腺癌早期骨转移有很高的诊断价值,但是具有放射性、特异性低、检查成本高的缺点。很多学者正在探索更加理想的筛查方法,一些研究发现可以用血清指标来早期诊断骨转移,如前列腺特异性抗原(PSA)、碱性磷酸酶(ALP)、骨吸收标志物抗酒石酸酸性磷酸酶5b(TRACP 5b)和血清Ⅰ型胶原吡啶交联终肽(1CTP)等。本文对早期筛查前列腺癌患者骨转移的血清学证据进行综述。

Chinese patients with prostate cancer have high proportion in the initial diagnosis of bone metastases, so early diagnosis has vital value for the treatment options and prognosis. Bone scan plays an important role in early diagnosis of prostate cancer, while with demerits, such as radioactivity, low specifi city and high cost. Better screening tools are needed. Serologic evidences, such as prostate specifi c antigen(PSA), alkaline phosphatase(ALP), tartrate-resistant acid phosphatase 5b(TRACP5b), carboxy-terminal pyridinoline cross-linked telopeptide parts of type-I collagen(1CPT), etc, have been found useful in detecting bone metastasis. This review summarizes serologic evidence in early detection of bone metastasis in patients with prostate cancer.