期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA甲基化与肺癌 被引量：1

DNA METHYLATION AND LUNG CANCER
下载PDF
导出
摘要 肺癌是发病率、死亡率较高的恶性肿瘤之一,近年来许多研究集中在对DNA甲基化与肺癌的发生发展的相互关系,了解DNA甲基化修饰异常在肺癌发生发展中的机制,从而有助于肺癌病人的早期发现、诊断、治疗和改善预后。 肺癌是发病率、死亡率较高的恶性肿瘤之一,近年来许多研究集中在对DNA甲基化与肺癌的发生发展的相互关系,了解DNA甲基化修饰异常在肺癌发生发展中的机制,从而有助于肺癌病人的早期发现、诊断、治疗和改善预后。
作者 孔凡 张翠英
机构地区 内蒙古医学院 内蒙古自治区人民医院肿瘤内科
出处 《内蒙古医科大学学报》 2012年第S2期228-232,共5页 Journal of Inner Mongolia Medical University
关键词 肺癌 DNA甲基化 lung cancer DNA methylation
分类号 R [医药卫生]
  • 相关文献

参考文献20

  • 1王海兵,陈晓峰.DNA甲基化在肺癌中的研究进展[J].中国肺癌杂志,2010,13(11):1074-1078. 被引量：10
  • 2孙昀,耿小平,朱立新.CDH13基因的研究进展[J].医学分子生物学杂志,2005,2(3):224-226. 被引量：5
  • 3Qureshi SA,Bashir MU,Yaqinuddin A.Utility of DNA methylation markers for diagnosing cancer. International Journal of Surgical Investigation . 2010
  • 4Pfeifer GP,Rauch TA.DNA methylation patterns in lung carcinomas. Seminars in Cancer Biology . 2009
  • 5Jin Y,Xu H,Zhang C,et al.Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer:a hospital-based case-control study in China. BMC Cancer . 2010
  • 6Ostrow KL,Hoque MO,Loyo M,et al.Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation -specific PCR. Clinical Cancer Research . 2010
  • 7Rouquette I,Mazieres J.A brief overview of a lung cancer biomarker:thymidylate synthase. Revue des Maladies Respiratoires . 2011
  • 8Toyooka S,Mitsudomi T,Soh J,et al.Molecular oncology of lung cancer. Gen Thorac Cardiovasc Surg . 2011
  • 9Begum S.Molecular changes in smoking-related lung cancer. Expert Review of Molecular Diagnostics . 2012
  • 10Sriram KB,Larsen JE,Yang IA, et al.Genomic medicine in non-small cell lung cancer: paving the path to personalized care. Respirology . 2011

二级参考文献33

  • 1王红兵,苗慧,张敬川,祖茂衡,蔡晓敏,吴秀英,胡西旦,迪力努,陈春玲.肺癌E-cadherin基因启动子CpG岛甲基化的研究[J].实用癌症杂志,2007,22(4):357-359. 被引量：5
  • 2Zucchini C,Bianchini M,Valvassori L,et al.Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone /kidney alkaline phosphatase gene.Bone,2004,34(4):672-9.
  • 3Goodsell DS.The molecular perlpective: cadherin. Oncologist,2002,7:467-8.
  • 4Wu Q,Maniatis T.Large exons encoding multiple edtodomains are a characteristic feature of protocadherin genes.Proc Natl Acad Sci USA,2000,97:3 124-9.
  • 5Tanihara H,Sano K,Heimark RL,et al.Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.Cell Adhes Commun,1994,2:15-26.
  • 6Roman-Gomez J,Castillejo JA,Jimenez A,et al.Cadherin-13,a mediator of calcium-dependent cell-cell adhesion,is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa.J Clin Oncol,2003,21:1 472-9.
  • 7Ranscht B,Dours-Zimmerman MT.T- cadherin,a novel cadherin cell adhesion molecule in the nervous system,lacks the conserved cytoplasmic region.Neuron,1991,7:391-402.
  • 8Lee SW.H-cadherin,a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nature Med,1996,2: 776-82.
  • 9Zhou SX,Matsuyoshi N,Liang SB, et al.Expression of T-Cadherin in Basal Keratinocytes of Skin.J Invest Dermatol,2002,118: 1 080 -4.
  • 10Masami S,Yuriko M,Akira S,et al.The H-cadherin (CDH 13) gene is inactivated in human lung cancer.Hum Genet,1998,103: 96-101.

共引文献13

同被引文献1

引证文献1

二级引证文献8

内蒙古医科大学学报
2012年 第S2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部