奉化市成年居民脂肪肝患病率及其危险因素流行病学调查

Epidemiological survey of prevalence of fatty liver and its risk factors in a general adult population of Fenghua

目的明确奉化市区成年居民脂肪肝患病率及其主要危险因素。方法通过多阶段分层随机抽样,对奉化市城区5个街道6个镇18岁以上居民进行调查,调查内容涉及问卷、体格检查、生化检测及肝胆B超检查。结果 95567例成人完成调查,占奉化市总人口的22.2%,脂肪肝患病率为19.86%,男性明显高于女性,脂肪肝组收缩压、舒张压、BMI、空腹血糖、超重肥胖、高血糖、血脂异常和高血压患病率均明显高于非脂肪肝组(P<0.01),多因素分析结果显示体重指数、甘油三酯、胆固醇、文化程度和舒张压等5项指标与脂肪肝密切相关。结论奉化市成年居民脂肪肝患病率高,超重肥胖及其相关的多元代谢紊乱与脂肪肝关系密切。

Objective To investigate the prevalence and major risk factors of fatty liver among adult residents in Fenghua. Methods A cross-sectional survey with multiple-stage stratified cluster and randomized sampling was performed. All residents aged 18 and above were invited to participate in the survey. They came from 5 streets and 6 pieces of districts. Questionnaire, physical examination, biochemistry test and ultrasonographic examination of liver and gallbladder were undertaken. Analysis of data was performed through SPSS 11.0 for Windows statistical package. Results Total of 95 567 residents took part in the survey, 22.2% of whom were Fenghua municipal residents. The prevalence of fatty liver was 19.86% and it is much higher in males than in females. The mean systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting serum glucose level, triglyceride (TG), total cholesterol (Tch) and the prevalence of ultra-body mass, obesity, high serum glucose, dyslipidemia and hypertension in the fatty liver group was significantly higher than those in the group without fatty liver (all P<0.01). Logistic regression analysis demonstrated that the prevalence of fatty liver was positively correlated to five risk factors including BMI, TG, Tch, educational level and diastolic blood pressure. Conclusions There is a high prevalence of fatty liver among adult residents in Fenghua. Metabolic disorders such as ultra-body mass and obesity, high serum glucose, dyslipidemia and hypertension are closely associated with fatty liver in Fenghua.