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癫痫发作和氧化应激的研究进展 被引量：4

Research Advances in Seizure and Oxidative Stress
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摘要 癫痫是一种常见的慢性神经疾病,其发病机制尚不完全明确,常需要长期的抗癫痫药物治疗,部分难治性癫痫的治疗也很棘手.在世界范围内约有七千万癫痫患者,在不同人群中癫痫的发病率大约是0.45%～0.817%.童年时期起病的癫痫患者有较高的死亡风险,除与本身疾病相关之外,也包括突然不可预料的死亡.近年来,有越来越多的证据表明癫痫发作与氧化应激有着密切的联系.拟对癫痫发作与氧化应激之间关系以及抗氧化、抗癫痫治疗的研究进展进行综述. 癫痫是一种常见的慢性神经疾病,其发病机制尚不完全明确,常需要长期的抗癫痫药物治疗,部分难治性癫痫的治疗也很棘手.在世界范围内约有七千万癫痫患者,在不同人群中癫痫的发病率大约是0.45%～0.817%.童年时期起病的癫痫患者有较高的死亡风险,除与本身疾病相关之外,也包括突然不可预料的死亡.近年来,有越来越多的证据表明癫痫发作与氧化应激有着密切的联系.拟对癫痫发作与氧化应激之间关系以及抗氧化、抗癫痫治疗的研究进展进行综述.
作者 杨娟 王文敏
机构地区 昆明医学院第一附属医院神经内科
出处 《昆明医科大学学报》 CAS 2012年第S1期232-235,共4页 Journal of Kunming Medical University
关键词 癫痫发作 氧化应激 抗氧化剂 Seizure Oxidative stress Antioxidant
分类号 R [医药卫生]
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参考文献20

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同被引文献37

  • 1刘磊,张静文,张新玥.牡荆苷调控Nrf2/ARE通路减轻急性脑缺血再灌注大鼠氧化应激反应研究[J].中草药,2020,51(5):1287-1293. 被引量：19
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  • 6Freitas R M, Nascimento K G, Ferreira P M, et al.Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures[J].Pharmacol Biochem Behav, 2010, 94 ( 3 ) : 341-345.
  • 7Grosso S, Longini M, Rodriguez A, et al.Oxidative stress in children affected by epileptic encephalopathies[J].Journal of the Neurological Sciences, 2011, 300 ( 1-2 ) : 103-106.
  • 8Agarwal N B, Jain S, Agarwal N K, et al.Modulation of pentylenetetrazole- induced kindling and oxidative stress by eurcumin in mice[J].Phytomedicine, 2011, 18 ( 8-9 ) : 756-759.
  • 9Shin E J, Jeong J H, Kim A Y, et al.Proteetion against kainate neurotoxieity by gnsenosides: attenuation of convulsive behavior, mitochondrial dysfunction, and oxidative stress[J].Journal of Neuroscience Research, 2009, 87 ( 3 ) : 710-722.
  • 10Zoccali C, Mallamaei F.Uric acid, hypertension, and cardiovascular and renal complications[J].Curr Hypertens Rep, 2013, 15 ( 6 ) : 531-537.

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昆明医科大学学报
2012年 第S1期

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