帕瑞昔布钠超前镇痛用于腹腔镜输尿管切开取石术的临床观察

Efficacy of parecoxib for preemptive analgesia in laparoscopic ureterolithotomy

目的:观察帕瑞昔布钠对腹腔镜输尿管切开取石术的超前镇痛效果及安全性。方法:择期行腹腔镜输尿管切开取石术患者50例,ASAⅠ~Ⅱ级,随机分为研究组和对照组。研究组麻醉诱导前静注帕瑞昔布钠40mg,对照组术毕前20 min静注帕瑞昔布钠40mg。记录观察2组术后30min、1h、4h、8h、12h、24hVAS评分,拔管后5、10、15、20min的Rammesay镇静评分及恶心、呕吐等不良反应的发生率。结果:研究组术后30min、1h、4h、8h、12、24h各时点VAS评分均低于对照组(P<0.05),研究组在5、10 min时的镇静评分高于对照组同时点(P<0.05),不良反应发生率差异无统计学意义(P>0.05)。结论:帕瑞昔布钠40mg超前镇痛用于腹腔镜输尿管切开取石术镇痛效果确切,不良反应发生率低,是较为理想的术后镇痛药物。

[Objective] To evaluate the effects of parecoxib for preemptive analgesia in patients undergoing laparoscopic ureterolithotomy.[Method] Fifty patients(ASA Ⅰ～Ⅱ) undergoing laparoscopic ureterolithotomy were randomly divided into research group and control group.Patients in research group were received parecoxib 40 mg before induction and patients in control group were received the same dose twenty minutes before the end of surgery.The effectiveness was assessed postoperatively using the visual analogue scale(VAS) at 30mins,1,4,8,12 and 24 hours after surgery.The scale of sedation was evaluated by Rammesay system at 5,10,15 and 20 min after surgery and the side effects were recorded.[Result] The VAS of patients in research group was significantly lower(P<0.05) than control group.The sedation scores in research group were higher than control group at 5 and 10 min(P<0.05).There was no significant difference between the two groups in side effects(P>0.05).[Conclusion] Parecoxib administered preemptively can provide effective postoperative analgesia for patients undergoing laparoscopic ureterolithotomy.