摘要
R-Enantiomer of the β-receptor antagonist N-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl] butanamide with high enantioselectivity was synthesized from cheap starting materials and enantiopure chiral reagent through an efficient,convenient and practical synthetic strategy.Title product was detected by 1H NMR,13C NMR,and MS,and the enatiomeric excess was determined by chiral HPLC analysis using a chiracel AD-H column.
R-Enantiomer of the β-receptor antagonist N-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl] butanamide with high enantioselectivity was synthesized from cheap starting materials and enantiopure chiral reagent through an efficient, convenient and practical synthetic strategy. Title product was detected by 1H NMR, 13C NMR, and MS, and the enatiomeric excess was determined by chiral HPLC analysis using a chiracel AD-H column.
作者
WANG NaiXing1,2 & TANG XinLiang1,3 1 Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100080,China
2 College of Chemistry and Chemical Engineering,Graduate University of Chinese Academy of Sciences,Beijing 100049,China
3 School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China
基金
Supported by the National Natural Science Foundation of China (Grant Nos. 20472090 & 10576034)
PLA General Armament Department (Grant No. 9140A28010707zk7301)
