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Circulating miRNA and cancer diagnosis 被引量：9

Circulating miRNA and cancer diagnosis
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摘要 miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area. miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area.
作者 TIE Yi1, LIU BinDong2, FU HanJiang1 & ZHENG XiaoFei1· 1 Beijing Institute of Radiation Medicine, Bejing 100850, China 2 Health Disparities/HIV Immed Ofc, Meharry Medical College, Nashville TN 37208, USA
出处 《Science China(Life Sciences)》 SCIE CAS 2009年第12期1117-1122,共6页 中国科学（生命科学英文版）
基金 Supported by the National Natural Science Foundation of China (Grant Nos. 30870529 and 30873008) Chinese Key Project for the Infectious Diseases (Grant No. 2008ZX10002-016)
关键词 CIRCULATING MIRNA CANCER DIAGNOSIS circulating miRNA, cancer, diagnosis
分类号 R730.4 [医药卫生—肿瘤]
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参考文献25

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二级参考文献56

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二级引证文献31

Science China(Life Sciences)
2009年 第12期

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