妊娠期高血压患者血清瘦素和胰岛素水平的变化

Study on changes of serum leptin and insulin levels in patients with gestational period hypertension

目的探讨血清瘦素(Leptin)、胰岛素(INS)与妊娠期高血压疾病发病的关系。方法采用放射免疫法测定46例HDCP患者和30例正常晚期妊娠妇女的空腹血清Leptin和INS水平,分析两者相关性,同时测量血糖。结果HDCP组血清Leptin、INS水平高于正常妊娠组(P<0.01),HDCP患者重度及轻度子痫前期组Leptin与INS水平均高于妊娠期高血压组(P<0.01);HDCP孕妇血清Leptin与INS水平呈明显正相关(P<0.05)。结论HDCP患者血清Leptin、INS水平均明显升高,可能共同参与了HDCP的发生和发展。

ObjectiveTo explore the changes of leptin and insulin levels in hypertensive disorder complicating pregnancy (HDCP).MethodsRadioimmunoassay was used to test the levels of fasting serum leptin and insulin in 46 patients with HDCP and 30 normal pregnant women. Their blood sugar and the body mass index (BMI) were also measured. The associativity of leptin and insulin was explored. ResultsLevels of leptin and insulin of HDCP group were significantly higher than those of normal pregnant women (P <0.01). The serum leptin level of mild preeclampasia was significantly higher than that of gestational period hypertension group (P <0.01); Leptin level of group HDCP was positively correlated to insulin level (P <0.05). ConclusionSerum leptin and insulin level obviously increased in pregnant women with HDCP, and they might participate the genesis and development of the disease.