阿尔茨海默病免疫治疗的困境与希望
摘要
阿尔茨海默病(AD)是一种常见的神经系统退行性疾病,是最常见的痴呆类型。目前,全球AD患者约有3560万,随着人口的老龄化,AD患者还将不断增加,但现时尚无有效的防治方法。自1984年发现β-
出处
《人民军医》
2011年第S1期69-71,共3页
People's Military Surgeon
参考文献10
-
1Vellas B,Coley N,Andrieu S.Disease modifying trials in Alzheimer’’sdisease:Perspectives for the future. Journal of Alzheimer s Disease . 2008
-
2Schor NF.What the halted phaseⅢgamma-secretase inhibitor trialmay (or may not)be telling us. Annals of Neurology . 2011
-
3Hyman BT.Amyloid-dependent and amyloid-independent stages ofAlzheimer disease. Archives of Neurology . 2011
-
4Wang YJ,Zhou HD,Zhou XF.Modified immunotherapies againstAlzheimer’’s disease:Toward safer and effective amyloid-beta clearance. Journal of Alzheimer s Disease . 2010
-
5Schenk D,Barbour R,Dunn W,et al.Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature . 1999
-
6Wang YJ,Zhou HD,Zhou XF.Clearance of amyloid-beta in Alzhei-mer’s disease:progress,problems and perspectives. Drug Discov To-day . 2006
-
7Holmes C,Boche D,Wilkinson D,et al.Long-term effects of Abeta42immunisation in Alzheimer‘s disease:follow-up of a randomised,placebo-controlled phase I trial. The Lancet . 2008
-
8ZS Khachaturian.Revised criteria for diagnosis of Alzheimer’s disease: National Institute on Aging-Alzheimer’s Association diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement . 2011
-
9Petrushina I,Ghochikyan A,Mktrichyan Met al.Alzheimer’’sdisease peptide vaccine reduces insoluble but not soluble/olimericAβspecies in Amyloid precursor protein transgenic mice. TheJournal of Neuroscience . 2007
-
10S Salloway,R Sperling,S Gilman,NC Fox,K Blennow,M Raskind,M Sabbagh,LS Honig,R Doody,CH Dyck,R Mulnard,J Barakos,KM Gregg,E Liu,I Lieberburg,D Schenk,R Black,M Grundman.A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology . 2009
-
1安忠民,苏建朝.困境中挣扎的军队医院[J].军事经济研究,1989(3):64-66.
-
2葛冉,吴小艾,李林.核医学显像在帕金森病中的应用现状及显像剂研究进展[J].中国介入影像与治疗学,2012,9(7):552-555. 被引量：1
-
3王晶.我国阿尔茨海默病的流行现状及预防措施[J].亚太传统医药,2011,7(2):157-158. 被引量：35
-
4王晓梅,穆长征,陶仕英.老年冠心病和冠状动脉造影特点[J].中国误诊学杂志,2005,5(6):1066-1067. 被引量：12
-
5汪建军,孙明,沈伟明.多层螺旋CT检查对肠缺血和肠坏死的诊断价值[J].浙江医学,2011,33(10):1539-1540. 被引量：1
-
6王奉国.把困境当作一只狗[J].养生大世界,2005(11A):23-23.
-
7程刚.肿瘤早期检查的重要性[J].保健医苑,2005(2):11-11. 被引量：1
-
8谌业维,杨小丽,李立红,孙亚梅,曾原琳,成晓娇,封欣蔚,杨咪.外资独资办医的困境及路径探析[J].医学争鸣,2016,37(2):11-14. 被引量：5
-
9王晓燕,肖继伟.腹腔内巨大囊性占位性病变的CT诊断困境探讨[J].江汉大学学报（自然科学版）,2010,38(2):96-100. 被引量：1
-
10冯桂梅,杨红,李英.大学生心理危机干预的困境与应对策略[J].中国卫生产业,2015,12(36):59-61. 被引量：4
